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Johan Flygare Selected Research

Diamond-Blackfan Anemia (Anemia, Diamond Blackfan)

1/2022Targeting elevated heme levels to treat a mouse model for Diamond-Blackfan Anemia.
1/2021The active component of ginseng, ginsenoside Rb1, improves erythropoiesis in models of Diamond-Blackfan anemia by targeting Nemo-like kinase.
1/2021Bone marrow transplantation without myeloablative conditioning in a mouse model for Diamond-Blackfan anemia corrects the disease phenotype.
11/2020Metformin-induced suppression of Nemo-like kinase improves erythropoiesis in preclinical models of Diamond-Blackfan anemia through induction of miR-26a.
10/2020Calmodulin inhibitors improve erythropoiesis in Diamond-Blackfan anemia.
9/2020The Role of α1-Microglobulin (A1M) in Erythropoiesis and Erythrocyte Homeostasis-Therapeutic Opportunities in Hemolytic Conditions.
1/2019A Phenotypic Screening Assay Identifies Modulators of Diamond Blackfan Anemia.
1/2017Lentiviral Vectors with Cellular Promoters Correct Anemia and Lethal Bone Marrow Failure in a Mouse Model for Diamond-Blackfan Anemia.
12/2014Gene therapy cures the anemia and lethal bone marrow failure in a mouse model of RPS19-deficient Diamond-Blackfan anemia.
9/2012Dietary L-leucine improves the anemia in a mouse model for Diamond-Blackfan anemia.
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Johan Flygare Research Topics

Disease

17Diamond-Blackfan Anemia (Anemia, Diamond Blackfan)
01/2022 - 05/2003
9Anemia
11/2020 - 07/2010
5Bone Marrow Failure Disorders
01/2019 - 12/2011
2Neoplasms (Cancer)
10/2020 - 02/2019
2Inflammation (Inflammations)
12/2011 - 07/2010
1Hemolysis
01/2021
1Spinocerebellar Ataxias (Spinocerebellar Ataxia)
11/2020
1Type 2 Diabetes Mellitus (MODY)
11/2020
1Myelodysplastic Syndromes (Myelodysplastic Syndrome)
09/2020
1Pre-Eclampsia (Preeclampsia)
09/2020
1Atherosclerosis
09/2020
1Hemorrhage
09/2020
1Wounds and Injuries (Trauma)
09/2020
1Osteolysis
02/2019
1Hypoxia (Hypoxemia)
03/2011
1Congenital Hypoplastic Anemia
11/2008

Drug/Important Bio-Agent (IBA)

10Ribosomal Proteins (Ribosomal Protein)IBA
01/2021 - 02/2007
7ribosomal protein S19IBA
01/2017 - 05/2003
3Heme (Haem)IBA
01/2022 - 09/2020
3GlucocorticoidsIBA
12/2011 - 07/2010
2Hemoglobins (Hemoglobin)IBA
01/2021 - 09/2012
2Phosphotransferases (Kinase)IBA
01/2021 - 11/2020
2ErythropoietinFDA Link
03/2011 - 07/2010
2Small Interfering RNA (siRNA)IBA
06/2005 - 04/2005
1ginsenoside Rb1IBA
01/2021
1Heme-Binding ProteinsIBA
01/2021
1Ascorbic Acid (Vitamin C)FDA LinkGeneric
01/2021
16- hydroxy- 2,5,7,8- tetramethylchroman- 2- carboxylic acid (Trolox)IBA
01/2021
1Vitamin EFDA LinkGeneric
01/2021
1Sirolimus (Rapamycin)FDA Link
01/2021
1Reducing AgentsIBA
01/2021
1HemopexinIBA
01/2021
1Pharmaceutical PreparationsIBA
11/2020
1HematinicsIBA
11/2020
1Metformin (Glucophage)FDA LinkGeneric
11/2020
1Proteins (Proteins, Gene)FDA Link
11/2020
1Calmodulin (Calcium-Dependent Activator Protein)IBA
10/2020
1Protein Subunits (Protein Subunit)IBA
10/2020
1Therapeutic UsesIBA
09/2020
1Peptide Elongation Factors (Elongation Factor)IBA
01/2017
1GlobinsIBA
01/2017
1DiamondIBA
11/2015
1Leucine (L-Leucine)FDA Link
09/2012
1Fibronectins (Fibronectin)IBA
07/2010

Therapy/Procedure

1Bone Marrow Transplantation (Transplantation, Bone Marrow)
01/2021
1Blood Transfusion (Blood Transfusions)
09/2020
1Therapeutics
02/2019
1Transplantation
11/2008